Fisetin attenuates cerulein-induced acute pancreatitis through down regulation of JNK and NF-κB signaling pathways.

Abstract

Acute pancreatitis (AP) is a complicated disease which is largely undiscovered. Fisetin, a natural flavonoid from fruits and vegetables, has been shown to have anti-inflammatory, antioxidant, and anti-cancer activities in various disease models. However, the effects of fisetin on AP have not been determined. Pre- and post- treatment of mice with fisetin reduced the severity of AP and pancreatitis-associated lung injury and inhibited several biochemical parameters (pancreatic weight to body weight ratio, amylase, lipase, and myeloperoxidase activity) and production of inflammatory cytokines. In pancreatic acinar cells, fisetin also inhibited cell death and production of inflammatory cytokines. In addition, fisetin inhibited activation of c-Jun NH2-terminal kinase (JNK) and nuclear factor (NF)-κB in vivo and in vitro. In conclusion, these results suggest that fisetin exhibits anti-inflammatory effect on AP and could be a beneficial agent in the treatment of AP and its pulmonary complications.

• Authors: Il-Joo Jo, Gi-Sang Bae, Sun Bok Choi, Dong-Goo Kim, Joon-Yeon Shin, Seung-Hee Seo, Mee-Ok Choi, Tae-Hyeon Kim, Ho-Joon Song, Sung-Joo Park
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 737 Pg. 149-58 (Aug 15 2014) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 24861022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Flavonoids
• Flavonols
• NF-kappa B
• Ceruletide
• JNK Mitogen-Activated Protein Kinases
• fisetin

Topics

• Acinar Cells (drug effects, pathology)
• Acute Disease
• Administration, Oral
• Animals
• Ceruletide (adverse effects)
• Down-Regulation (drug effects)
• Enzyme Activation (drug effects)
• Female
• Flavonoids (administration & dosage, pharmacology, therapeutic use)
• Flavonols
• Injections, Intraperitoneal
• JNK Mitogen-Activated Protein Kinases (metabolism)
• Lung (drug effects, pathology)
• Mice
• Mice, Inbred C57BL
• NF-kappa B (metabolism)
• Pancreas (drug effects, pathology)
• Pancreatitis (chemically induced, drug therapy, pathology, prevention & control)
• Signal Transduction (drug effects)