Myocardial remodeling following
myocardial infarction (MI) is emerging as key causes of chronic
infarct mortality.
Interleukin-6 is a classic pro-inflammatory
cytokine needed to mount an effective immune response. It seems that
interleukin-6 acts as an important role in the dynamic and superbly orchestrated process of innate immunity after MI.
Interleukin-6 timely suppresses of innate immune signals to prevent the catastrophic consequences of uncontrolled
inflammation on cardiac geometry and function, and thus tunes myocardial remodeling. A comprehensive understanding of biological processes of
interleukin-6 in innate immunity leading to inflammatory response and disease-related
ventricular remodeling is helpful to find the
solution of chronic
heart failure. To accomplish this, we reviewed the articles of
interleukin-6 regard to
inflammation, innate immunity, and cardiac remodeling. This review focuses on the role of
interleukin-6 that dominates cell-mediated immunity, especially on neutrophils, monocytes, macrophages, and fibroblasts. In addition, we will also briefly discuss other inflammatory
cytokines involved in this process within the paper.