Leukocytoclastic vasculitis as a complication of recombinant granulocyte colony-stimulating factor therapy in a heart transplant patient.

Abstract

Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many mechanisms that collectively induce an increase in neutrophil function and a subsequent release of cytokines. Here, we report a case of leukocytoclastic vasculitis proven by skin biopsy, following the use of rG-CSF in a heart transplant patient with leukopenia secondary to immunosuppressive therapy.

• Authors: Giovanbattista Ippoliti, Marco Paulli, Marco Lucioni, Marinella Lauriola, Andrea Maria D'Armini
• Journal: Case reports in transplantation (Case Rep Transplant) Vol. 2014 Pg. 160407 ( 2014) ISSN: 2090-6943 [Print] United States
• PMID: 24600524 (Publication Type: Journal Article)