EBV-positive MTX-diffuse large B cell lymphoma in a rheumatoid arthritis patient.

Abstract

Methotrexate (MTX)-associated lymphoproliferative disorders have received much attention from rheumatologists, and early diagnosis is very important for reducing mortality. There are several reports of radiologic findings in patients with pulmonary malignant lymphoma, mainly consisting of masses, nodules, and lymphadenopathy. Computed tomography has rarely detected necrosis in the masses. In this article, we report a case of MTX-associated Epstein-Barr virus-positive diffuse large B-cell lymphoma characterized by a very large lung mass with prominent areas of central necrosis. The disease regressed after withdrawal of MTX.

• Authors: Kouhei Tokuyama, Fumito Okada, Shunro Matsumoto, Hiromu Mori, Masao Ogata, Erika Omote, Toru Yamasaki, Syougo Urabe
• Journal: Japanese journal of radiology (Jpn J Radiol) Vol. 32 Issue 3 Pg. 183-7 (Mar 2014) ISSN: 1867-108X [Electronic] Japan
• PMID: 24408079 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antirheumatic Agents
• Contrast Media
• Methotrexate

Topics

• Aged
• Antirheumatic Agents (adverse effects, therapeutic use)
• Arthritis, Rheumatoid (complications, drug therapy)
• Biopsy
• Contrast Media
• Diagnosis, Differential
• Epstein-Barr Virus Infections (complications, diagnosis)
• Female
• Follow-Up Studies
• Humans
• In Situ Hybridization (methods)
• Lymph Nodes (diagnostic imaging, pathology)
• Lymphoma, Large B-Cell, Diffuse (chemically induced, complications, diagnosis)
• Methotrexate (adverse effects, therapeutic use)
• Positron-Emission Tomography (methods)
• Radiographic Image Enhancement (methods)
• Tomography, X-Ray Computed (methods)