This report presents the recommendations of a WHO expert committee commissioned to coordinate activities leading to the adoption of international recommendations for the production and control of
vaccines and other biologicals and the establishment of international biological reference materials. The report starts with a discussion of general issues brought to the attention of the Committee and provides information on the status and development of reference materials for various
antibodies,
antigens, blood products and related substances,
cytokines,
growth factors, endocrinological substances and
in vitro diagnostic devices. The second part of the report, of particular relevance to manufacturers and national regulatory authorities, contains revised WHO Recommendations for evaluation of animal cell cultures as substrates for the manufacture of biological medicinal products, for production and control of
hepatitis B vaccines and for production and control of
yellow fever vaccines. New WHO Guidelines on the independent lot release of
vaccines are also included. Finally, there is an update to the procedure for the prequalification of
vaccines. Also included are lists of Recommendations, Guidelines and other documents related to the manufacture and control of biological substances used in medicine, and of International Standards and Reference
Reagents for biological substances.