Bioactive lipids in pathological retinopathy.

Abstract

Diabetic retinopathy is a common condition that occurs in patients with diabetes with long-standing hyperglycemia that is characterized by inappropriate angiogenesis. This pathological angiogenesis could be a sort of physiological proliferative response to injury by the endothelium. Recent studies suggested that reactive oxygen species (ROS) play a significant role in this angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that plays a significant role in diabetic retinopathy. The interaction between VEGF and ROS, and theirs in turn with pro- and anti-inflammatory cytokines and anti-inflammatory bioactive lipid molecules such as lipoxins, resolvins, protectins, and maresins is particularly relevant to understand the pathophysiology of diabetic retinopathy and develop future therapeutic interventions.

• Authors: Qi Ma, Jun-Hui Shen, Sheng-Rong Shen, Undurti N Das
• Journal: Critical reviews in food science and nutrition (Crit Rev Food Sci Nutr) Vol. 54 Issue 1 Pg. 1-16 ( 2014) ISSN: 1549-7852 [Electronic] United States
• PMID: 24188230 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-Inflammatory Agents
• Cytokines
• Fatty Acids, Essential
• Lipids
• Lipoxins
• Polyesters
• Reactive Oxygen Species
• Vascular Endothelial Growth Factor A
• poly(lactide-co-trimethylene carbonate)
• Vascular Endothelial Growth Factor Receptor-2

Topics

• Anti-Inflammatory Agents
• Cytokines (physiology)
• Diabetic Retinopathy (physiopathology)
• Fatty Acids, Essential (metabolism)
• Humans
• Lipids (physiology)
• Lipoxins (physiology)
• Neovascularization, Pathologic (physiopathology)
• Polyesters
• Reactive Oxygen Species
• Vascular Endothelial Growth Factor A (physiology)
• Vascular Endothelial Growth Factor Receptor-2 (physiology)