Abstract | AIM: METHODS: RESULTS:
Chemotherapy ± G-CSF mobilized immature cells (CD34(+)CD38(-) population), while the more mature cells (CD34(+)CD38(low) and CD34(+)CD38(+) populations) decreased progressively after treatment. Circulating CD34(+) cells tended to be more sensitive to chemotherapy after priming with G-CSF. CD34(+) cell mobilization was correlated with a gradual increase in CXCR4 and CD47 expression, suggesting a role in cell protection and the capacity of homing back to the marrow. CONCLUSION:
Chemotherapy ± G-CSF mobilizes into the circulation CD34(+) bone marrow cells, of which, the immature CD34(+)CD38(-) cell population. Further manipulations of these interactions may be a means with which to control the trafficking of leukemia stem cells to improve patients' outcomes.
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Authors | Adriana Plesa, Youcef Chelghoum, Eve Mattei, Hélène Labussière, Mohamed Elhamri, Giovanna Cannas, Stéphane Morisset, Inès Tagoug, Mauricette Michallet, Charles Dumontet, Xavier Thomas |
Journal | World journal of stem cells
(World J Stem Cells)
Vol. 5
Issue 4
Pg. 196-204
(Oct 26 2013)
ISSN: 1948-0210 [Print] United States |
PMID | 24179607
(Publication Type: Journal Article)
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