Abstract | OBJECTIVE: METHODS: RESULTS: The mean Cmax and AUC0-24 of rifabutin in patients on rifabutin 150 mg every other day were 36% and 26% lower than on 300 mg/day rifabutin, while the mean Cmax and AUC0-24 of 25-O-desacetyl rifabutin were 186% and 152% higher, respectively. The plasma concentrations of rifabutin plus its metabolite were similar between the groups within the first 24 hours, but it remained low during subsequent 24 to 48 hours under rifabutin 150 mg alternate day dosing. CONCLUSION:
Rifabutin dose of 150 mg every other day combined with lopinavir- ritonavir seems to be associated with lower exposure to rifabutin and its metabolite compared with rifabutin 300 mg/day alone in Japanese patients. Further studies are needed to establish the optimal rifabutin dose during ART. The results highlight the importance of monitoring rifabutin plasma concentration during ART. TRIAL REGISTRATION: UMIN-CTR (https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=search&action=input&language=E) UMIN000001102.
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Authors | Junko Tanuma, Kazumi Sano, Katsuji Teruya, Koji Watanabe, Takahiro Aoki, Haruhito Honda, Hirohisa Yazaki, Kunihisa Tsukada, Hiroyuki Gatanaga, Yoshimi Kikuchi, Shinichi Oka |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 8
Pg. e70611
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23940604
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HIV Protease Inhibitors
- Rifabutin
- Lopinavir
- Ritonavir
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Topics |
- Adult
- Drug Administration Schedule
- Drug Interactions
- Female
- HIV Infections
(blood, drug therapy)
- HIV Protease Inhibitors
(pharmacokinetics, therapeutic use)
- Humans
- Lopinavir
(pharmacokinetics, therapeutic use)
- Male
- Middle Aged
- Rifabutin
(pharmacokinetics, therapeutic use)
- Ritonavir
(pharmacokinetics, therapeutic use)
- Young Adult
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