Abstract | CONTEXT: OBJECTIVE: MATERIALS AND METHODS: RESULTS: TBMS1 significantly inhibited the production of the pro-inflammatory cytokines, TNF-α, IL-6 and IL-1β in vitro and in vivo. Pretreatment with TBMS1 markedly attenuated the development of pulmonary edema, histological severities and inflammatory cells infiltration in mice with ALI. In addition, we further demonstrated that TBMS1 exerts an anti-inflammatory effect in vivo model of ALI through suppression of IκB activation and p38/ extracellular signal-regulated kinase mitogen-activated protein kinases signaling in a dose-dependent manner. DISCUSSION AND CONCLUSION: Overall, our data suggest that TBMS1 inhibits inflammation both in vitro and in vivo, and may be a potential therapeutic candidate for the prevention of inflammatory diseases.
|
Authors | Qianchao Wu, Guoquan Sun, Xue Yuan, Lanan Wassy Soromou, Na Chen, Ying Xiong, Haihua Feng |
Journal | Immunopharmacology and immunotoxicology
(Immunopharmacol Immunotoxicol)
Vol. 35
Issue 4
Pg. 514-23
(Aug 2013)
ISSN: 1532-2513 [Electronic] England |
PMID | 23844578
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Cytokines
- Lipopolysaccharides
- Saponins
- Triterpenes
- tubeimoside I
|
Topics |
- Acute Lung Injury
(chemically induced, immunology, pathology, prevention & control)
- Animals
- Cell Line
- Cytokines
(immunology)
- Inflammation
(chemically induced, immunology, pathology, prevention & control)
- Lipopolysaccharides
(toxicity)
- Macrophages
(immunology, pathology)
- Male
- Mice
- Mice, Inbred BALB C
- Pulmonary Edema
(chemically induced, immunology, pathology, prevention & control)
- Saponins
(pharmacology)
- Triterpenes
(pharmacology)
|