Abstract | BACKGROUND: METHODS: We investigated the dysregulation of expression of selected cytokines and chemokines in the serum of MKD patients. The results have been compared with those observed in an MKD mouse model obtained by treating the mice with aminobisphosphonate, a molecule that is able to inhibit the cholesterol pathway, mimicking the genetic block characteristic of the disease. RESULTS:
Interleukin (IL)-1β, IL-5, IL-6, IL-9, IL-17, granulocyte colony-stimulating factor, monocyte chemotactic protein-1, tumor necrosis factor-α, and IL-4 expression were dysregulated in sera from MKD patients and mice. Moreover, geraniol, an exogenous isoprenoid, when administered to MKD mice, restored cytokines and chemokines levels with values similar to those of untreated mice. CONCLUSION: Our findings, which were obtained in patients and a mouse model mimicking the human disease, suggest that these cytokines and chemokines could be MKD specific and that isoprenoids could be considered as potential therapeutic molecules. The mouse model, even if with some limitations, was robust and suitable for routine testing of potential MKD drugs.
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Authors | Annalisa Marcuzzi, Valentina Zanin, Giulio Kleiner, Lorenzo Monasta, Sergio Crovella |
Journal | Pediatric research
(Pediatr Res)
Vol. 74
Issue 3
Pg. 266-71
(Sep 2013)
ISSN: 1530-0447 [Electronic] United States |
PMID | 23760140
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acyclic Monoterpenes
- Chemokines
- Cytokines
- Diphosphonates
- Terpenes
- geraniol
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Topics |
- Acyclic Monoterpenes
- Animals
- Chemokines
(blood)
- Cytokines
(blood)
- Diphosphonates
(pharmacology)
- Disease Models, Animal
- Gene Expression Regulation
(drug effects, immunology)
- Humans
- Mevalonate Kinase Deficiency
(immunology)
- Mice
- Species Specificity
- Terpenes
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