Expression of genes for interleukin-1 alpha and tumour necrosis factor-alpha in newborn mice.

Abstract

Spleen cells from newborn mice are immunologically non-reactive and do not respond by proliferation to T- or B-cell mitogens. However, they synthesize significant levels of mRNA for interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) after mitogen stimulation. Since these two cytokines mediate many protective activities in the body, they may be important in ensuring the survival of immunologically immature newborns.

• Authors: M Lipoldová, V Holán
• Journal: Immunology (Immunology) Vol. 70 Issue 1 Pg. 136-7 (May 1990) ISSN: 0019-2805 [Print] England
• PMID: 2354858 (Publication Type: Journal Article)

Chemical References

• Interleukin-1
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Animals, Newborn (genetics)
• Gene Expression
• Interleukin-1 (genetics)
• Mice
• Tumor Necrosis Factor-alpha (genetics)