Angiogenic and inflammatory markers in acute respiratory distress syndrome and renal injury associated to A/H1N1 virus infection.

Abstract

Acute kidney injury (AKI) is often associated to acute respiratory distress syndrome (ARDS) due to influenza A/H1N1 virus infection. The profile of angiogenic and inflammatory factors in ARDS patients may be relevant for AKI. We analyzed the serum levels of several angiogenic factors, cytokines, and chemokines in 32 patients with A/H1N1 virus infection (17 with ARDS/AKI and 15 ARDS patients who did not developed AKI) and in 18 healthy controls. Significantly higher levels of VEGF, MCP-1, IL-6, IL-8 and IP-10 in ARDS/AKI patients were detected. Adjusting by confusing variables, levels of MCP-1 ≥150 pg/mL (OR=12.0, p=0.04) and VEGF ≥225 pg/mL (OR=6.4, p=0.03) were associated with the development of AKI in ARDS patients. Higher levels of MCP-1 and IP-10 were significantly associated with a higher risk of death in patients with ARDS (hazard ratio (HR)=10.0, p=0.02; HR=25.5, p=0.03, respectively) even taking into account AKI. Patients with influenza A/H1N1 infection and ARDS/AKI have an over-production of MCP-1, VEGF and IP-10 possibly contributing to kidney injury and are associated to a higher risk of death.

• Authors: Edgar Bautista, Magali Arcos, Luís Jimenez-Alvarez, Ma Cecilia García-Sancho, María E Vázquez, Erika Peña, Anjarath Higuera, Gustavo Ramírez, Rosario Fernández-Plata, Alfredo Cruz-Lagunas, Sara A García-Moreno, Francisco Urrea, Remedios Ramírez, Ricardo Correa-Rotter, José Rogelio Pérez-Padilla, Joaquín Zúñiga
• Journal: Experimental and molecular pathology (Exp Mol Pathol) Vol. 94 Issue 3 Pg. 486-92 (Jun 2013) ISSN: 1096-0945 [Electronic] Netherlands
• PMID: 23542734 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Angiogenic Proteins
• Biomarkers
• CCL2 protein, human
• CXCL10 protein, human
• Chemokine CCL2
• Chemokine CXCL10
• Vascular Endothelial Growth Factor A

Topics

• Acute Kidney Injury (metabolism, mortality, virology)
• Adult
• Angiogenic Proteins (metabolism)
• Biomarkers (metabolism)
• Chemokine CCL2 (metabolism)
• Chemokine CXCL10 (metabolism)
• Female
• Humans
• Inflammation (metabolism)
• Influenza A Virus, H1N1 Subtype (isolation & purification)
• Influenza, Human (complications, metabolism, mortality)
• Male
• Mexico (epidemiology)
• Neovascularization, Pathologic (metabolism)
• Respiratory Distress Syndrome (metabolism, mortality, virology)
• Survival Rate
• Vascular Endothelial Growth Factor A (metabolism)