Abstract | INTRODUCTION AND OBJECTIVES: MATERIAL AND METHODS: Twenty-one patients with severe psoriasis ( psoriasis area severity index and body surface area>10) and 11 healthy controls with no dermatologic disease were studied. Cardiovascular risk factors were assessed according to the Adult Treatment Panel ( ATP) III criteria. Subclinical carotid atheromatosis was assessed by Doppler ultrasonography of the carotid arteries. Plasma clusterin and MIF levels were measured by enzyme-linked immunosorbent assay. RESULTS:
ATP-III criteria for metabolic syndrome were met by 47% of the patients, and 33% had carotid atheromatous plaque. Mean (SD) clusterin plasma levels were significantly lower in patients with psoriasis compared with controls (81.39 [27.30] μg/mL for the 21 patients vs 117 [21.6] μg/mL for the 11 controls; P=.0017). MIF plasma levels (ng/ml) were significantly higher in patients with atheromatous plaque compared with controls (53.22 [29.02] for the 6 patients with plaque vs 34.21 [9.65] for the 11 controls; P=.0394). CONCLUSIONS: The decreased plasma levels of clusterin in psoriatic patients suggested an association with the disease and might be an indicator of systemic inflammatory activity. Increased levels of MIF appear to be associated with cardiovascular risk factors and carotid atheromatous plaque.
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Authors | S García-Rodríguez, S Arias-Santiago, R Perandrés-López, J Orgaz-Molina, L Castellote, A Buendía-Eisman, J C Ruiz, R Naranjo, P Navarro, J Sancho, M Zubiaur |
Journal | Actas dermo-sifiliograficas
(Actas Dermosifiliogr)
2013 Jul-Aug
Vol. 104
Issue 6
Pg. 497-503
ISSN: 1578-2190 [Electronic] Spain |
PMID | 23522962
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier España, S.L. and AEDV. All rights reserved. |
Chemical References |
- Clusterin
- Macrophage Migration-Inhibitory Factors
- Intramolecular Oxidoreductases
- MIF protein, human
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Topics |
- Adult
- Cardiovascular Diseases
(blood, epidemiology)
- Clusterin
(blood)
- Female
- Humans
- Intramolecular Oxidoreductases
(blood)
- Macrophage Migration-Inhibitory Factors
(blood)
- Male
- Middle Aged
- Psoriasis
(blood)
- Risk Factors
- Severity of Illness Index
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