Relationship of pentraxin 3 with insulin sensitivity in gestational diabetes.

Abstract

BACKGROUND:

Pentraxin 3 (PTX3) is a cytokine-inducible molecule expressed in different tissues, the levels of which increase in a response to a variety of inflammatory conditions. Recently, it has been linked to the serum glucose levels and some comorbidities in type 2 diabetes.

MATERIALS AND METHODS:

Here, we aimed to investigate the role of PTX3 in gestational diabetes mellitus (GDM), which is considered a forerunner of type 2 diabetes. Fasting PTX3 serum levels were measured in 90 women [45 GDM, 45 normal glucose tolerance (NGT)] during pregnancy. In addition, PTX3 was measured during a 2 h, 75 g oral glucose tolerance test (OGTT) in 20 women (10 GDM, 10 NGT) at 24-28 weeks of gestation and in 16 of them after delivery (10GDM, 6 NGT).

RESULTS:

A continuous increase in PTX3 levels was observed during the OGTT and reached in the GDM group a significant difference after 120 min compared with baseline (P < 0·05). Additionally, a rise in the PTX3 concentration was significantly higher in the GDM- compared with the NGT group, 120 min after glucose challenge (P < 0·01). During pregnancy, serum glucose and C-peptide were positively correlated with the PTX3 levels in the whole study group, whereas a negative association was found with the insulin sensitivity parameters QUICKI and OGIS.

CONCLUSIONS:

Dependence of PTX3 on serum glucose levels was more pronounced in women with GDM than in the NGT group. This notion together with its inverse relation to the parameters of insulin sensitivity, suggests a potential involvement of PTX3 in GDM pathology.

• Authors: Jelena Todoric, Ammon Handisurya, Bernhard Knapp, Andrea Tura, Giovanni Pacini, Alexandra Kautzky-Willer
• Journal: European journal of clinical investigation (Eur J Clin Invest) Vol. 43 Issue 4 Pg. 341-9 (Apr 2013) ISSN: 1365-2362 [Electronic] England
• PMID: 23379644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 The Authors. European Journal of Clinical Investigation © 2013 Stichting European Society for Clinical Investigation Journal Foundation.

Chemical References

• Blood Glucose
• Insulin
• Serum Amyloid P-Component
• PTX3 protein
• C-Reactive Protein

Topics

• Adult
• Blood Glucose (metabolism)
• C-Reactive Protein (metabolism)
• Diabetes Mellitus, Type 2 (blood)
• Diabetes, Gestational (blood, diagnosis)
• Female
• Glucose Tolerance Test
• Humans
• Insulin (blood)
• Insulin Resistance
• Pregnancy
• Regression Analysis
• Serum Amyloid P-Component (metabolism)