Effects of exchange transfusion on cytokine profiles in necrotizing enterocolitis.

Abstract

To study the effect of exchange transfusion on cytokine profiles in a patient with necrotizing enterocolitis, the levels of 12 cytokines and serum calprotectin were measured among exchange transfusion. A male extremely low birth weight infant was in non-compensated shock and diagnosed stage 3 necrotizing enterocolitis. Exchange transfusion was performed for critical condition, refractory hypotension and disseminated intravascular coagulation. After exchange transfusion, the patient's blood pressure increased and stabilized. Then an enterostomy was performed and revealed necrosis of the ascending colon. Of the cytokines examined, interleukin-8 and serum calprotectin were high before exchange transfusion and decreased after exchange transfusion.

• Authors: Tokio Sugiura, Masanori Kouwaki, Kenji Goto, Takeshi Endo, Koichi Ito, Norihisa Koyama, Hajime Togari
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 54 Issue 6 Pg. 931-3 (Dec 2012) ISSN: 1442-200X [Electronic] Australia
• PMID: 23279025 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.

Chemical References

• Cytokines

Topics

• Cytokines (blood)
• Enterocolitis, Necrotizing (blood, therapy)
• Exchange Transfusion, Whole Blood (methods)
• Humans
• Infant, Extremely Premature
• Infant, Newborn
• Male