Interleukin-17 (IL-17) expression is reduced during acute myocardial infarction: role on chemokine receptor expression in monocytes and their in vitro chemotaxis towards chemokines.
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| Abstract |
The roles of immune cells and their soluble products during myocardial infarction (MI) are not completely understood. Here, we observed that the percentages of IL-17, but not IL-22, producing cells are reduced in mice splenocytes after developing MI. To correlate this finding with the functional activity of IL-17, we sought to determine its effect on monocytes. In particular, we presumed that this cytokine might affect the chemotaxis of monocytes important for cardiac inflammation and remodeling. We observed that IL-17 tends to reduce the expression of two major chemokine receptors involved in monocyte chemotaxis, namely CCR2 and CXCR4. Further analysis showed that monocytes pretreated with IL-17 have reduced in vitro chemotaxis towards the ligand for CCR2, i.e., MCP-1/CCL2, and the ligand for CXCR4, i.e., SDF-1α/CXCL12. Our results support the possibility that IL-17 may be beneficial in MI, and this could be due to its ability to inhibit the migration of monocytes.
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| Authors | Maria Troitskaya, Anton Baysa, Jarle Vaage, Kristin L Sand, Azzam A Maghazachi, Guro Valen |
| Journal | Toxins (Toxins (Basel)) Vol. 4 Issue 12 Pg. 1427-39 (Nov 30 2012) ISSN: 2072-6651 [Electronic] Switzerland |
| PMID | 23202375 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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