Abstract | BACKGROUND AND AIMS: Although systemic corticosteroids are successfully administered for the induction of clinical response and remission in the majority of patients with inflammatory bowel disease (IBD) presenting with a flare, a proportion of these patients demonstrate a primary nonresponse to steroids or in the case of an initial response, they develop a resistance or a steroid dependence. Long-term therapy with corticosteroids for treatment of IBD should be avoided, given the high frequency of adverse treatment effects. Knowledge about treatment strategies in case of steroid nonresponse is therefore highly relevant. METHODS: A systematic literature research was performed using Medline and Embase to summarize the currently recommended treatment strategies for steroid-resistant IBD. RESULTS: CONCLUSION: This review summarizes the current evidence for treating steroid-resistant IBD.
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Authors | Michael Manz, Stephan R Vavricka, Roger Wanner, Peter L Lakatos, Gerhard Rogler, Pascal Frei, Ekaterina Safroneeva, Alain M Schoepfer |
Journal | Digestion
(Digestion)
Vol. 86 Suppl 1
Pg. 11-5
( 2012)
ISSN: 1421-9867 [Electronic] Switzerland |
PMID | 23051721
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Immunosuppressive Agents
- Prednisolone
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Topics |
- Anti-Inflammatory Agents
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Colitis, Ulcerative
(drug therapy)
- Crohn Disease
(drug therapy)
- Drug Resistance
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Induction Chemotherapy
- Maintenance Chemotherapy
- Prednisolone
(therapeutic use)
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