Therapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis.

Abstract

α-Iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, strongly enhances survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. Mechanistically, α-iso-cubebenol markedly reduces viable bacteria in the peritoneal fluid and peripheral blood, by increasing production of superoxide anion. α-Iso-cubebenol also significantly attenuates widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibits the production of proinflammatory cytokines including interleukin-1β (IL-1β) and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes. Taken together, the results indicate that α-iso-cubebenol can reverse the progression of septic shock by triggering multiple protective downstream signaling pathways to enhance microbial killing and maintain organ function and leukocyte survival.

• Authors: Sung Kyun Lee, Sang Doo Kim, Minsoo Kook, Ha Young Lee, Joon Seong Park, Young Hoon Park, Jum Soon Kang, Won Jung Jung, Young Whan Choi, Yoe-Sik Bae
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 427 Issue 3 Pg. 547-52 (Oct 26 2012) ISSN: 1090-2104 [Electronic] United States
• PMID: 23022181 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Biological Products
• Sesquiterpenes
• alpha-iso-cubebenol

Topics

• Animals
• Bacteria (drug effects)
• Biological Products (therapeutic use)
• Disease Models, Animal
• Fruit (chemistry)
• Male
• Mice
• Mice, Inbred ICR
• Schisandra (chemistry)
• Sepsis (drug therapy)
• Sesquiterpenes (administration & dosage, therapeutic use)