Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.

Abstract

Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods.

• Authors: Ali Mobasheri, Yves Henrotin, Hans-Konrad Biesalski, Mehdi Shakibaei
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 13 Issue 4 Pg. 4202-4232 ( 2012) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 22605974 (Publication Type: Journal Article, Review)

Chemical References

• Angiogenesis Inhibitors
• Anti-Inflammatory Agents, Non-Steroidal
• IL1B protein, human
• Interleukin-1beta
• Phytochemicals
• RELA protein, human
• Stilbenes
• Transcription Factor RelA
• Tumor Necrosis Factor-alpha
• Curcumin
• Resveratrol

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Arthritis, Rheumatoid (drug therapy, pathology)
• Cartilage, Articular (pathology, physiology)
• Chondrocytes (metabolism)
• Curcumin (therapeutic use)
• Humans
• Inflammation (drug therapy)
• Interleukin-1beta (immunology)
• Joints (pathology)
• Osteoarthritis (drug therapy, pathology)
• Phytochemicals (therapeutic use)
• Phytotherapy (methods)
• Resveratrol
• Stilbenes (therapeutic use)
• Transcription Factor RelA (metabolism)
• Tumor Necrosis Factor-alpha (immunology)