Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects.

Abstract

BACKGROUND:

Th17 cell lineage, a distinct pro-inflammatory lineage characterized by preferential synthesis of cytokines IL-17A and IL-17F, is thought to play an important role in the pathogenesis of allergic rhinitis (AR).

OBJECTIVES:

Our aim was to investigate whether polymorphisms in and around IL-17A and IL-17F genes are associated with AR and comorbid asthma.

METHODS:

A case-control comparison was performed in a cohort of 279 AR patients, 197 allergic rhinitis with asthma (AR-A) patients and 281 control Chinese subjects, to investigate associations between 19 tagging single-nucleotide polymorphisms (SNPs) in IL-17A and IL-17F gene regions and manifestation of AR or AR-A. Genotyping was performed using the Sequenom MassARRAY platform.

RESULTS:

SNP rs3819024 in IL-17A gene, intergenic SNPs rs1892280 and rs10807439 were specifically associated with AR protective or risk effects, while rs3819024 in IL-17A gene, intergenic SNP rs13192563 in IL-17F gene were associated with AR-A protective or risk effects. Haplotype analysis showed significant AR risk in haplotype AA (rs1892280G-rs13192563A) and AR protective effect in haplotype GT (rs7758579A-rs11966760T); the haplotype AT(rs7758579-rs11966760) were considered AR-A risk.

CONCLUSIONS:

Our findings preliminarily indicate IL17A and IL17F SNPs, and some intergenic variants have the potential association with AR and comorbid asthma in Chinese population.

• Authors: Min Wang, Yuan Zhang, Demin Han, Luo Zhang
• Journal: Human immunology (Hum Immunol) Vol. 73 Issue 6 Pg. 647-53 (Jun 2012) ISSN: 1879-1166 [Electronic] United States
• PMID: 22507625 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Human Immunology. Published by Elsevier Inc. All rights reserved.

Chemical References

• IL17A protein, human
• IL17F protein, human
• Interleukin-17

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Asthma (epidemiology, genetics, immunology)
• Case-Control Studies
• Child
• Child, Preschool
• China (epidemiology)
• Cohort Studies
• Comorbidity
• DNA Fingerprinting
• Female
• Genetic Association Studies
• Haplotypes
• Humans
• Interleukin-17 (genetics, immunology)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Rhinitis, Allergic, Perennial (epidemiology, genetics, immunology)
• Th17 Cells (immunology, metabolism)