Abstract | BACKGROUND: METHODS: Serum CYFRA levels were measured at baseline and after the first cycle of treatment using an electrochemoluminescent assay. Paired specimens were available from 88 patients. The logarithms of the initial concentration and of the difference in concentrations were analyzed for association with overall survival (OS) and failure-free survival (FFS). RESULTS: Lower baseline CYFRA levels were associated with both longer OS and FFS (p < 0.0001 and p = 0.0003). In addition, larger reductions in CYFRA levels correlated with longer OS and FFS (p = 0.0255 and p = 0.0068). CONCLUSION: CYFRA and change in CYFRA were found to be reliable markers for response to chemotherapy for NSCLC; however, a precise threshold to mark response has yet to be determined.
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Authors | Martin J Edelman, Lydia Hodgson, Paula Y Rosenblatt, Robert H Christenson, Everett E Vokes, Xiaofei Wang, Robert Kratzke |
Journal | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
(J Thorac Oncol)
Vol. 7
Issue 4
Pg. 649-54
(Apr 2012)
ISSN: 1556-1380 [Electronic] United States |
PMID | 22425913
(Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Keratin-19
- antigen CYFRA21.1
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Topics |
- Adult
- Aged
- Antigens, Neoplasm
(blood)
- Biomarkers, Tumor
(blood)
- Carcinoma, Non-Small-Cell Lung
(blood, mortality, pathology)
- Female
- Humans
- Keratin-19
(blood)
- Lung Neoplasms
(blood, mortality, pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Prospective Studies
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