Pretreatment of cisplatin in recipients attenuates post-transplantation pancreatitis in murine model.

Abstract

Pancreas transplantation is the definite treatment for type 1 diabetes that enables the achievement of long-term normoglycemia and insulin independence. However Post-Transplantation Pancreatitis (PTP) due to ischemia reperfusion (IR) injury and preservation is a major complication in pancreas transplantation. Owning the potential anti-inflammatory effect of Cisplatin (Cis) in liver IR injury, we have examined if Cis could attenuate PTP using a murine model. We found that Cis is able to prevent inflammatory response in PTP. Pretreatment of Cis in recipient mice reduce the impairments of the grafts and hyperamylasimea in the recipients. We documented that the protective mechanism of Cis in PTP involves improvement of microcirculation, reduction of the mononuclear cellular infiltration and apoptosis, suppression of inflammatory cytokine-cascade and inhibition of translocation of high-motility group box protein-1 (HMGB-1) from nucleus to cytoplasm. In short, our study demonstrated that pretreatment of Cis in recipients may reduce the onset of PTP in pancreas transplantation.

• Authors: Sheng Yan, Yuan Ding, Fei Sun, Zhongjie Lu, Liang Xue, Xiangyan Liu, Mingqi Shuai, Chen Fang, Yan Wang, Hui Cheng, Lin Zhou, Ming H Zheng, Shusen Zheng
• Journal: International journal of biological sciences (Int J Biol Sci) Vol. 8 Issue 3 Pg. 298-309 ( 2012) ISSN: 1449-2288 [Electronic] Australia
• PMID: 22355266 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• HMGB1 Protein
• Cisplatin

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Apoptosis (drug effects)
• Cell Nucleus (drug effects, metabolism)
• Cisplatin (administration & dosage, therapeutic use)
• Drug Evaluation, Preclinical
• Graft Rejection (prevention & control)
• HMGB1 Protein (metabolism)
• Male
• Mice
• Mice, Inbred BALB C
• Microcirculation
• Microscopy, Fluorescence
• Pancreas (blood supply, drug effects, ultrastructure)
• Pancreas Transplantation
• Pancreatitis (etiology, prevention & control)
• Postoperative Complications (etiology, prevention & control)
• Premedication
• Protein Transport (drug effects)
• Specific Pathogen-Free Organisms