Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma.

Abstract

Marine algae have been utilized in food as well as medicine products for a variety of purposes. The purpose of this study was to determine whether an ethanol extract of Polyopes affinis (P.affinis) can inhibit the pathogenesis of T helper 2 (Th2)-mediated allergen-induced airway inflammation in a murine model of asthma. Mice that were sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic reactions such as the following: an increase in the number of eosinophils in the bronchoalveolar lavage (BAL) fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways as well as the narrowing of the airway luminal; the development of airway hyperresponsiveness (AHR); the presence of pulmonary Th2 cytokines; and the presence of allergenspecific immunoglobulin E (IgE) in the serum. The successive intraperitoneal administration of P. affinis ethanolic extracts before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These data suggest that P. affinis ethanolic extracts possess therapeutic potential for the treatment of pulmonary allergic disorders such as allergic asthma.

• Authors: Dae-Sung Lee, Won Sun Park, Soo-Jin Heo, Seon-Heui Cha, Daekyung Kim, You-Jin Jeon, Sae-Gwang Park, Su-Kil Seo, Jung Sik Choi, Sung-Jae Park, Eun Bo Shim, Il-Whan Choi, Won-Kyo Jung
• Journal: Journal of biosciences (J Biosci) Vol. 36 Issue 5 Pg. 869-77 (Dec 2011) ISSN: 0973-7138 [Electronic] India
• PMID: 22116285 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Asthmatic Agents
• Cytokines
• Free Radical Scavengers
• Plant Extracts
• Solvents
• Immunoglobulin E
• Ethanol
• Ovalbumin
• Peroxidase

Topics

• Animals
• Anti-Asthmatic Agents (isolation & purification, pharmacology)
• Asthma (chemically induced, drug therapy)
• Bronchoalveolar Lavage Fluid
• Cytokines (metabolism)
• Disease Models, Animal
• Eosinophils (enzymology)
• Ethanol (chemistry)
• Female
• Free Radical Scavengers (isolation & purification, pharmacology)
• Immunoglobulin E (blood)
• Lung (drug effects, metabolism, pathology)
• Mice
• Mice, Inbred BALB C
• Ovalbumin
• Peroxidase (metabolism)
• Plant Extracts (isolation & purification, pharmacology)
• Rhodophyta (chemistry)
• Solvents (chemistry)