Soft coagulation, polyglycolic acid felt, and fibrin glue for prevention of pancreatic fistula after distal pancreatectomy.

Abstract

PURPOSE:

To evaluate the effectiveness of using soft coagulation followed by the application of polyglycolic acid (PGA) felt and fibrin glue to prevent pancreatic fistula (PF) after distal pancreatectomy (DP).

METHODS:

A soft coagulation system was applied on the cut surface of the pancreas after ligating the main pancreatic duct, followed by the application of layers of PGA felt and fibrin glue on the layers, to prevent the development of a PF after DP.

RESULTS:

This technique was applied in nine patients, with mean drain amylase levels of 372 ± 296, 185 ± 209, 54 ± 40, and 47 ± 34 IU/l on days 1, 3, 5, and 7, respectively, after DP. Only one patient (11.1%) showed a Grade A PF on day 3 after surgery; none of the other patients developed a fistula.

CONCLUSIONS:

This technique is an effective prophylactic measure to prevent the development of a PF after DP.

• Authors: Toru Ikegami, Takashi Maeda, Hiroto Kayashima, Eiji Oki, Tomoharu Yoshizumi, Yoshihisa Sakaguchi, Yasushi Toh, Ken Shirabe, Yoshihiko Maehara
• Journal: Surgery today (Surg Today) Vol. 41 Issue 9 Pg. 1224-7 (Sep 2011) ISSN: 1436-2813 [Electronic] Japan
• PMID: 21874419 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Fibrin Tissue Adhesive
• Tissue Adhesives
• Polyglycolic Acid

Topics

• Aged
• Female
• Fibrin Tissue Adhesive
• Hemostasis, Surgical (methods)
• Humans
• Male
• Middle Aged
• Pancreatectomy (methods)
• Pancreatic Fistula (etiology, prevention & control)
• Pancreatic Neoplasms (surgery)
• Polyglycolic Acid
• Postoperative Complications (prevention & control)
• Tissue Adhesives
• Treatment Outcome