Abstract | INTRODUCTION:
Adenosine is an endogenous nucleoside that accumulates in the extracellular space in response to metabolic stress and cell damage. Extracellular adenosine is a signaling molecule that signals by activating four GPCRs: the A(1), A(2A), A(2B) and A(3) receptors. Since the discovery of A(3) adenosine receptors, accumulating evidence has identified these receptors as potential targets for therapeutic intervention. AREAS COVERED: A(3) adenosine receptors are expressed on the surface of most immune cell types, including neutrophils, macrophages, dendritic cells, lymphocytes and mast cells. A(3) adenosine receptor activation on immune cells governs a broad array of immune cell functions, which include cytokine production, degranulation, chemotaxis, cytotoxicity, apoptosis and proliferation. In accordance with their multitudinous immunoregulatory actions, targeting A(3) adenosine receptors has been shown to impact the course of a wide spectrum of immune-related diseases, such as asthma, rheumatoid arthritis, cancer, ischemia and inflammatory disorders. EXPERT OPINION:
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Authors | Balázs Koscsó, Balázs Csóka, Pál Pacher, György Haskó |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 20
Issue 6
Pg. 757-68
(Jun 2011)
ISSN: 1744-7658 [Electronic] England |
PMID | 21457061
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Adenosine A3 Receptor Agonists
- Adenosine A3 Receptor Antagonists
- Ligands
- Receptor, Adenosine A3
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Topics |
- Adenosine A3 Receptor Agonists
(pharmacology)
- Adenosine A3 Receptor Antagonists
(pharmacology)
- Animals
- Drug Delivery Systems
- Drug Design
- Humans
- Immune System Diseases
(drug therapy, physiopathology)
- Ligands
- Receptor, Adenosine A3
(drug effects, immunology, metabolism)
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