[Inflammasomes and related diseases].

Abstract

Although inflammation is important for host defense, excessive inflammation sometimes causes serious consequences. IL-1β is one of major proinflammatory cytokines. Dysregulation of IL-1β promotes development of several diseases. Mature IL-1β is produced by cleavage of its proform by a protein complex named inflammasome. Inflammasome consists of NOD-LRRs containing family (NLR proteins), an adaptor protein, and a cysteine protease caspase-1. Several NLRs can be assembled into inflammasome in response to various stimulatory signals. Genetic disorder of inflammasome-IL-1 system cause autoinflammatory diseases such as cryopyrin-associated autoinflammatory disease, familial Mediterranean fever, deficiency of IL-1 receptor antagonist, and PAPA syndrome. This article reviews recent advances in the study of inflammasome and related diseases.

• Authors: Megumu K Saito
• Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology (Nihon Rinsho Meneki Gakkai Kaishi) Vol. 34 Issue 1 Pg. 20-8 ( 2011) ISSN: 1349-7413 [Electronic] Japan
• PMID: 21372510 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Inflammasomes
• Interleukin-1

Topics

• Autoimmune Diseases (immunology)
• Disease Susceptibility
• Humans
• Inflammasomes (immunology)
• Inflammation (immunology)
• Interleukin-1 (immunology)