Effect of cilostazol administration on cerebral hemodynamics and rehabilitation outcomes in poststroke patients.

Abstract

PRIMARY OBJECTIVE:

Cilostazol is an antiplatelet agent that inhibits phosphodiesterase III in platelets and the vascular endothelium. We assessed the effects of cilostazol on human cerebral hemodynamics and rehabilitation outcomes.

RESEARCH DESIGN:

Prospective, consecutive, observational trial with pretreatment and posttreatment evaluations.

EXPERIMENTAL INTERVENTIONS:

Cilostazol (200 mg/day) administered for 8 weeks.

METHODS AND PROCEDURES:

Cerebral blood flow at rest, cerebrovascular reserve capacity, and rehabilitation outcomes (Brunnstrom stage, Barthel index score, modified Rankin Scale score, and Mini-Mental State Examination score) were measured in 104 poststroke patients with an average age ± standard deviation of 60.8 ± 9.2 years.

MAIN OUTCOMES AND RESULTS:

The cerebral blood flow increased by 23.8% on the affected side of the brain and by 16.9% on the nonaffected side. The cerebrovascular reserve capacity increased by 19.0% on the affected side of the brain and by 13.3% on the nonaffected side. Improvements were observed in the Brunnstrom stage, Barthel index score, modified Rankin Scale score, and Mini-Mental State Examination score.

CONCLUSIONS:

Cilostazol appeared to have beneficial effects in poststroke patients with cerebral ischemia and might improve cerebral circulation and rehabilitation outcome.

• Authors: Shuji Matsumoto, Megumi Shimodozono, Ryuji Miyata, Kazumi Kawahira
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 121 Issue 5 Pg. 271-8 (May 2011) ISSN: 1563-5279 [Electronic] England
• PMID: 21348793 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Tetrazoles
• Vasodilator Agents
• Cilostazol

Topics

• Adult
• Aged
• Brain Ischemia (drug therapy, rehabilitation)
• Cerebral Arteries (drug effects, physiology)
• Cerebrovascular Circulation (drug effects, physiology)
• Cilostazol
• Female
• Hemodynamics (drug effects, physiology)
• Humans
• Male
• Middle Aged
• Outcome Assessment, Health Care (methods)
• Physical Therapy Modalities
• Prospective Studies
• Stroke (drug therapy)
• Stroke Rehabilitation
• Tetrazoles (administration & dosage, adverse effects)
• Treatment Outcome
• Vasodilator Agents (administration & dosage, adverse effects)
• Young Adult