Cilostazol (Pletal)

A quinoline and tetrazole derivative that acts as a phosphodiesterase type 3 inhibitor, with anti-platelet and vasodilating activity. It is used in the treatment of PERIPHERAL VASCULAR DISEASES; ISCHEMIC HEART DISEASE; and in the prevention of stroke.

Also Known As:

Networked: 1212 relevant articles (250 outcomes, 391 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hong, Ki Whan: 34 articles (01/2020 - 03/2002)
2.	Kim, Chi Dae: 25 articles (01/2020 - 09/2003)
3.	Park, So Youn: 25 articles (01/2020 - 03/2004)
4.	Lee, Won Suk: 24 articles (01/2020 - 09/2003)
5.	Kwon, Sun U: 22 articles (12/2021 - 04/2005)
6.	Shin, Hwa Kyoung: 18 articles (01/2019 - 03/2002)
7.	Uchiyama, Shinichiro: 17 articles (07/2022 - 11/2003)
8.	Lee, Jeong Hyun: 17 articles (08/2010 - 03/2002)
9.	Hong, Keun-Sik: 15 articles (01/2022 - 04/2005)
10.	Kim, Jong S: 15 articles (01/2021 - 04/2005)

Related Diseases

1.	Intermittent Claudication 11/01/2006 - "Cilostazol is a potent selective inhibitor of phosphodiesterase-3 of proven efficacy in intermittent claudication. " 01/01/2003 - "In six of eight well designed clinical trials, cilostazol was significantly more effective than placebo in increasing walking distances and improving the quality of life of patients with moderate to severe intermittent claudication. " 01/01/2003 - ", double-blind, placebo-controlled 12- to 24-week trials in >2000 patients with moderate to severe intermittent claudication demonstrated that cilostazol generally significantly increased walking distances and improved quality of life compared with placebo. " 04/01/2020 - "Conclusions: Three months cilostazol treatment significantly improved quality of life and lower limb functional capacity in patients with intermittent claudication. " 08/10/2013 - "Cilostazol has been found to be effective for the treatment of intermittent claudication (IC). "
2.	Stroke (Strokes) 08/24/2015 - "More randomized controlled trials in non-East Asian patients are needed to determine whether long-term use of cilostazol is the best option for the prevention of recurrent stroke." 12/15/2005 - "In the Cilostazol Stroke Prevention Study, a randomized double-blind, placebo-controlled trial involving more than 1000 Japanese patients, cilostazol was found to reduce the risk of secondary stroke by 41.7% compared with placebo, a statistically significant reduction (P = 0.015). " 10/01/2023 - "Clinical studies assessing the efficacy of cilostazol in the management of stroke and MMD were recently reported, although a comprehensive assessment of the overall evidence is lacking. " 05/01/2014 - "However, the efficacy of cilostazol on preventing CIMT progression in stroke patients has never been investigated properly by a prospective trial. " 06/01/2012 - "Clinical and pathological improvement in stroke-prone spontaneous hypertensive rats related to the pleiotropic effect of cilostazol."
3.	Ischemic Stroke 01/01/2020 - "Conclusions- Cilostazol may be more beneficial for ischemic stroke patients with multiple cerebral microbleeds and before white matter changes are extensive. " 01/01/2008 - "Antiplatelet cilostazol is beneficial in diabetic and/or hypertensive ischemic stroke patients. " 01/01/2022 - "Cilostazol improves endothelial function in patients with ischemic stroke: A randomized controlled single-center study with flow-mediated dilation technique." 12/06/2013 - "To study the efficacy and safety of cilostazol on ischemic stroke prevention and treatment, systematic reviews of related clinical randomized controlled trials were analyzed. " 03/01/2012 - "Further large-scale studies in more heterogeneous study populations are warranted to determine whether cilostazol is a viable therapeutic option for patients with a history of non-cardioembolic ischemic stroke."
4.	Thrombosis (Thrombus) 04/01/2010 - "The purpose of this study was to investigate the efficacy of cilostazol for prevention of thrombosis in microsurgical anastomosis. " 01/01/2008 - "The aim of this study was to investigate effects of cilostazol and K-134 on thrombus formation and neointimal thickening at the site of prosthetic graft replacement. " 01/01/2023 - "Reported odds ratios were calculated using a 2 × 2 contingency table, and a signal was considered present if the lower limit of the 95% confidence interval was >1. In combination with cilostazol, a hemorrhagic signal for OPZ in JADER and arterial emboli and thrombus signals for EPZ were detected in both databases. " 08/01/2020 - "After adding cilostazol 200 mg, recanalization was successfully obtained by thrombus aspiration and ballooning under intra-aortic balloon pump. " 05/01/2012 - "Cilostazol is frequently used to treat and prevent thrombosis in Korean patients. "
5.	Cerebral Infarction 01/01/2012 - "In both cohorts, cilostazol significantly suppressed focal no-reflow, mitigated cerebral infarct, and improved neurological outcome. " 12/01/2000 - "More recently, cilostazol was shown to be effective in a clinical prevention study on recurrence of cerebral infarction, and has been applied to the approval of the indication in Japan." 10/01/2012 - "Cilostazol has been shown to be effective for prevention and treatment of cerebral infarction. " 01/01/2011 - "Several reports have indicated that cilostazol is effective in the prevention of recurrence after cerebral infarction. " 03/01/2002 - "This study examined the protective effects of cilostazol on cerebral infarcts produced by subjecting rats to 2-h occlusion of the left middle cerebral artery followed by 24-h reperfusion. "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Clopidogrel (Plavix)
3.	Phosphoric Diester Hydrolases (Phosphodiesterases)
4.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)
5.	Phosphodiesterase Inhibitors
6.	Lipids
7.	Pentoxifylline (Trental)
8.	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))
9.	Type 3 Cyclic Nucleotide Phosphodiesterases
10.	Phosphodiesterase 3 Inhibitors

Related Therapies and Procedures

1.	Therapeutics
2.	Stents
3.	Secondary Prevention
4.	Oral Administration
5.	Drug-Eluting Stents