Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS: Increased levels of sialyl Lewis X ( SLe(x) ) were detected on AGP in advanced PaC and CP and on HPT, FET, AT and TRF in CP. An increase in N- glycan branching was detected on AGP and HPT in the advanced stage of PaC and CP and on FET and TRF in the CP. A core fucosylated structure was increased on AGP and HPT only in the advanced PaC patients. CONCLUSIONS AND CLINICAL RELEVANCE: Changes in APP SLe(x) and branching are probably associated with an inflammatory response because they were detected in both advanced PaC and CP patients and these conditions give rise to inflammation. On the contrary, the increase in APP core fucosylation could be cancer associated and the presence of this glycoform may give an advantage to the tumour.
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Authors | Ariadna Sarrats, Radka Saldova, Eva Pla, Esther Fort, David J Harvey, Weston B Struwe, Rafael de Llorens, Pauline M Rudd, Rosa Peracaula |
Journal | Proteomics. Clinical applications
(Proteomics Clin Appl)
Vol. 4
Issue 4
Pg. 432-48
(Apr 2010)
ISSN: 1862-8354 [Electronic] Germany |
PMID | 21137062
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Acute-Phase Proteins
- Biomarkers
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Topics |
- Acute-Phase Proteins
(metabolism)
- Adult
- Aged
- Biomarkers
(blood)
- Female
- Glycosylation
- Humans
- Liver
(physiopathology)
- Male
- Middle Aged
- Pancreatic Neoplasms
(metabolism, physiopathology)
- Pancreatitis, Chronic
(metabolism, physiopathology)
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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