Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice.

Abstract

We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.

• Authors: Takayuki Ohbuchi, Makoto Sakaino, Tetsunari Takahashi, Naoya Azumi, Kotaro Ishikawa, Sadahiro Kawazoe, Yukiko Kobayashi, Yasuhiro Kido
• Journal: Journal of nutritional science and vitaminology (J Nutr Sci Vitaminol (Tokyo)) Vol. 56 Issue 1 Pg. 54-9 ( 2010) ISSN: 1881-7742 [Electronic] Japan
• PMID: 20354347 (Publication Type: Journal Article)

Chemical References

• Acids
• Oligosaccharides
• Plant Extracts
• Interleukin-12
• Immunoglobulin E
• Histamine

Topics

• Acids
• Administration, Oral
• Animals
• Cells, Cultured
• Dermatitis, Atopic (immunology, pathology, prevention & control)
• Histamine (blood)
• Immunoglobulin E (blood)
• Interleukin-12 (metabolism)
• Lymphocytes (drug effects)
• Magnoliopsida
• Male
• Mice
• Mice, Inbred Strains
• Oligosaccharides (administration & dosage, pharmacology, therapeutic use)
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Skin (drug effects, immunology, pathology)
• Spleen (cytology)
• Wood