Abstract | BACKGROUND: The rat sepsis model in the present study was used to understand the role of sustained hyperglycemia and ovariectomy, either separately or together, on the response of pro-inflammatory mediators and oxidative response. MATERIALS AND METHODS: RESULTS: In lung, heart, and liver tissues, the levels of myeloperoxidase (MPO) and lipid peroxidation (LPO) were higher for the groups 3, 4, and 5 than in control group. In heart and liver tissues, superoxide dismutase (SOD) and catalase (CAT) activities were higher for the groups 3, 4, and 5 than control group. In lung tissue SOD activities were higher for the groups 3, 4, and 5 than in control group. Diabetes + ovariectomy caused a significant increase in serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) in comparison to the sham group. The strongest production of TNF-α and IL-6 in serum was observed in the group 5. CONCLUSIONS:
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Authors | Ayse Albayrak, M Hamidullah Uyanik, Fehmi Odabasoglu, Zekai Halici, Abdullah Uyanik, Yasin Bayir, Fatih Albayrak, Yavuz Albayrak, Beyzagul Polat, Halis Suleyman |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 169
Issue 1
Pg. 67-75
(Jul 2011)
ISSN: 1095-8673 [Electronic] United States |
PMID | 20080253
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Cytokines
- Tumor Necrosis Factor-alpha
- Alloxan
- Catalase
- Peroxidase
- Superoxide Dismutase
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Topics |
- Alloxan
- Animals
- Antioxidants
(metabolism)
- Catalase
(blood)
- Cytokines
(metabolism)
- Diabetes Mellitus, Experimental
(chemically induced, metabolism)
- Disease Models, Animal
- Female
- Hyperglycemia
(metabolism)
- Lipid Peroxidation
(physiology)
- Liver
(metabolism)
- Lung
(metabolism)
- Myocardium
(metabolism)
- Ovariectomy
- Peroxidase
(metabolism)
- Rats
- Rats, Wistar
- Sepsis
(metabolism)
- Superoxide Dismutase
(metabolism)
- Tumor Necrosis Factor-alpha
(blood)
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