Abstract | BACKGROUND: A large number of studies point toward chronic aspiration associated with gastroesophageal reflux disease ( GERD) as an important factor involved in the development of asthma, the incidence of which has increased dramatically in industrially developed countries. Recent work suggests that medical intervention aimed at acid blockade is not sufficient to relieve the effects of chronic aspiration on asthma pathology, leaving surgical treatment of the disease as one of the few remaining options. This study examined the effect of chronic aspiration on the airway-associated immune response to allergens using a model of experimentally induced airway hypersensitivity in Balb/c mice. METHODS: The mice received aspiration of gastric fluid on days 1, 8, 15, 22, 29, 36, 43, and 50 and were sensitized to ovalbumin by intraperitoneal (IP) injection on days 33 and 47, challenged with aerosolized ovalbumin on day 54, and killed on day 56. Control mice received sham gastric fluid aspirations, sham induction of airway hypersensitivity, or both. RESULTS: CONCLUSIONS: The results indicate that chronic aspiration of gastric fluid has a profound effect on the nature of the allergic response to aerosolized allergens, suggesting that the aspiration may be an important factor affecting the pathogenesis of asthma.
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Authors | Anitra D Thomas, Kuei-Ying Su, Jui-Chih Chang, Jason H Leung, Sean M Lee, Zoie E Holzknecht, Mary Lou Everett, William Parker, R Duane Davis, Shu S Lin |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 24
Issue 5
Pg. 1066-74
(May 2010)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 19915914
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-5
- Tumor Necrosis Factor-alpha
- Interleukin-12
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Topics |
- Animals
- Asthma
(etiology, immunology)
- Disease Models, Animal
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Follow-Up Studies
- Gastric Acid
(metabolism)
- Gastroesophageal Reflux
(complications, metabolism)
- Immunity, Cellular
- Interleukin-12
(immunology)
- Interleukin-5
(biosynthesis)
- Lung
(immunology, metabolism)
- Macrophages, Alveolar
(immunology, metabolism)
- Male
- Mice
- Mice, Inbred BALB C
- T-Lymphocytes
(immunology)
- Tumor Necrosis Factor-alpha
(immunology)
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