3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease.

Abstract

AIM:

The aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (CA1), extract from Centella Asiatica, in rats subjected to experimental colitis.

RESULTS:

Colitis was induced in rats by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). CA1 was administered daily orally (0.2 or 2 mg/kg). Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight. This was associated with a significant reduction in colonic MPO activity. CA1 also reduced NF-kappaB activation, the pro-inflammatory cytokines release, the appearance of I-NOS, nitrotyrosine, PARP and proMMP-9 and -2 activity in the colon and reduced the up-regulation of ICAM-1 and the expression of P-Selectin.

CONCLUSIONS:

The results of this study suggested that administration of CA1 may be beneficial for treatment of inflammatory bowel disease.

• Authors: Rosanna di Paola, Emanuela Esposito, Emanuela Mazzon, Rocco Caminiti, Roberto Dal Toso, Giovanna Pressi, Salvatore Cozzocrea
• Journal: Free radical research (Free Radic Res) Vol. 44 Issue 1 Pg. 74-89 (Jan 2010) ISSN: 1029-2470 [Electronic] England
• PMID: 19886745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3,5-dicaffeoyl-4-malonylquinic acid
• Anti-Inflammatory Agents
• Caffeic Acids
• Centella asiatica extract
• Plant Extracts
• Triterpenes
• Quinic Acid
• Chlorogenic Acid

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Caffeic Acids (pharmacology, therapeutic use)
• Cells, Cultured
• Centella
• Chlorogenic Acid (analogs & derivatives)
• Colon (drug effects, metabolism, pathology)
• Disease Models, Animal
• Down-Regulation (drug effects)
• Drug Evaluation, Preclinical
• Inflammation (drug therapy, metabolism, pathology)
• Inflammatory Bowel Diseases (drug therapy, immunology, metabolism, pathology)
• Male
• Models, Biological
• Oxidative Stress (drug effects)
• Plant Extracts
• Quinic Acid (analogs & derivatives, pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Triterpenes (pharmacology)