Abstract | OBJECTIVE: METHODS: We therefore conducted a 4-month double-blind clinical trial in 28 obese [mean body mass index (BMI): 40.3 +/- 5.7 kg/m(2)], insulin-resistant [homeostasis model assessment - insulin resistance: 7.6 +/- 2.8 and whole body insulin sensitivity index (WBISI): 1.5 +/- 0.7] adolescents (age 15.0 +/- 1.3 yr) randomized to MET (n = 15, dose 1500 mg daily) or placebo (n = 13). RESULTS: The treatment with MET was well tolerated. MET treatment was associated with a decreased BMI (p = 0.02) as well as with a reduction in subcutaneous fat (p = 0.03), particularly the deep subcutaneous fat (p = 0.04) as assessed by magnetic resonance imaging. Postintervention, the MET group had a 35% improvement in insulin sensitivity (WBISI) compared with the placebo group (p = 0.008). However, significance was lost with adjustments for differences in baseline insulin sensitivity (p = 0.09). While there was no change in inflammatory cytokines or lipid parameters, cardiovascular function as assessed by heart rate recovery after exercise improved with MET and worsened in placebo (p = 0.03). CONCLUSION: Short-term use of MET is well tolerated by obese children with NGT and has a beneficial effect on BMI and autonomic control of the heart as well as a trend toward improved insulin sensitivity. Thus, long-term treatment with MET may provide a means to ameliorate the cardio-metabolic consequences of adolescent obesity.
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Authors | Tania S Burgert, Elvira J Duran, Rachel Goldberg-Gell, James Dziura, Catherine W Yeckel, Stuart Katz, William V Tamborlane, Sonia Caprio |
Journal | Pediatric diabetes
(Pediatr Diabetes)
Vol. 9
Issue 6
Pg. 567-76
(Dec 2008)
ISSN: 1399-5448 [Electronic] Denmark |
PMID | 18761646
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypoglycemic Agents
- Metformin
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Topics |
- Adolescent
- Body Mass Index
- Carbohydrate Metabolism
- Cardiovascular Diseases
(etiology)
- Exercise Test
- Female
- Glucose Tolerance Test
- Heart Rate
(drug effects)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Insulin Resistance
- Male
- Metformin
(therapeutic use)
- Obesity
(complications, drug therapy, metabolism)
- Risk Factors
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