Abstract | AIM: METHODS: RESULTS: Linear hemorrhagic mucosal lesions were observed primarily in the glandular stomach 4 h after oral administration of indomethacin. Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner. The mucosal concentrations of proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-8) and MPO, which indicates the degree of mucosal infiltration by neutrophils, increased concomitantly with the occurrence of gastric injury in the indomethacin-treated rats. Pretreatment with irsogladine maleate significantly decreased the levels of these inflammatory factors in gastric tissue elicited by indomethacin. CONCLUSION: The mucosal protective effects afforded by irsogladine maleate on gastric injury induced by indomethacin are mediated by inhibition of mucosal proinflammatory cytokine production and neutrophil infiltration, leading to suppression of mucosal inflammation and subsequent tissue destruction.
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Authors | Xin Zhang, Koyuki Tajima, Kiyoto Kageyama, Takashi Kyoi |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 14
Issue 30
Pg. 4784-90
(Aug 14 2008)
ISSN: 1007-9327 [Print] United States |
PMID | 18720540
(Publication Type: Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Cytokines
- Interleukin-1beta
- Interleukin-8
- Phosphodiesterase 4 Inhibitors
- Phosphodiesterase Inhibitors
- Triazines
- Tumor Necrosis Factor-alpha
- Peroxidase
- Cyclic Nucleotide Phosphodiesterases, Type 4
- irsogladine
- Indomethacin
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Topics |
- Animals
- Anti-Ulcer Agents
(pharmacology)
- Cyclic Nucleotide Phosphodiesterases, Type 4
(metabolism)
- Cytokines
(metabolism)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Gastric Mucosa
(drug effects, immunology, pathology)
- Indomethacin
- Interleukin-1beta
(metabolism)
- Interleukin-8
(metabolism)
- Male
- Peroxidase
(metabolism)
- Phosphodiesterase 4 Inhibitors
- Phosphodiesterase Inhibitors
(pharmacology)
- Rats
- Stomach Ulcer
(chemically induced, immunology, pathology, prevention & control)
- Time Factors
- Triazines
(pharmacology)
- Tumor Necrosis Factor-alpha
(metabolism)
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