Polymorphisms of RANTES and IL-4 genes in cerebral infarction.

Abstract

Chemoattractant peptides (chemokines) and cytokines have been shown to play a key role in the inflammatory development and progression of cerebrovascular disease. The effect of polymorphisms in regulated upon activation, normal T cells expressed, and secreted (RANTES) and interleukin-4 (IL-4) genes on cerebral infarction (CI) is evaluated in this study. Patients with CI (n = 320) and healthy controls (n = 481) were genotyped for RANTES-403 and IL-4 variable number of tandem repeat (VNTR) polymorphisms using polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism. A significant difference was observed between the CI group and controls in subjects with the RANTES AA genotype in IL-4 A3- carriers (18.6% vs. 13.1%, P = 0.035, odds ratio = 1.5, 95% confidence interval = 1.03-2.25). These findings suggest that the RANTES G-403A allele increased the relative risk for CI in the subjects without the IL-4 VNTR allele 3.

• Authors: Jae-Young Um, Hyung-Min Kim
• Journal: Journal of molecular neuroscience : MN (J Mol Neurosci) Vol. 37 Issue 1 Pg. 1-5 (Jan 2009) ISSN: 0895-8696 [Print] United States
• PMID: 18696265 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CCL5 protein, human
• Chemokine CCL5
• IL4 protein, human
• Interleukin-4

Topics

• Asian People (genetics, statistics & numerical data)
• Cerebral Infarction (ethnology, genetics)
• Chemokine CCL5 (genetics)
• Genetic Predisposition to Disease (ethnology)
• Genotype
• Humans
• Interleukin-4 (genetics)
• Korea (epidemiology)
• Polymorphism, Genetic
• Risk Factors