Abstract | BACKGROUND: Demyelinating strains of Theiler's murine encephalomyelitis virus (TMEV) such as the DA strain are the causative agents of a persistent infection that induce a multiple sclerosis-like disease in the central nervous system of susceptible mice. Viral persistence, mainly associated with macrophages, is considered to be an important disease determinant that leads to chronic inflammation, demyelination and autoimmunity. In a previous study, we described the establishment of a persistent DA infection in RAW macrophages, which were therefore named DRAW. RESULTS: CONCLUSION: We have identified several compounds that modulate viral replication in an in vitro model system for TMEV persistence. These compounds now await further testing in an in vivo setting to address fundamental questions regarding persistent viral infection and immunopathogenesis.
|
Authors | Stephane Steurbaut, Ellen Merckx, Bart Rombaut, Raf Vrijsen |
Journal | Virology journal
(Virol J)
Vol. 5
Pg. 89
(Aug 04 2008)
ISSN: 1743-422X [Electronic] England |
PMID | 18680564
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiviral Agents
- Ccl5 protein, mouse
- Chemokine CCL5
- Cytokines
|
Topics |
- Animals
- Antiviral Agents
(pharmacology)
- Cardiovirus Infections
(drug therapy, genetics, immunology)
- Cell Line
- Cell Survival
(drug effects)
- Chemokine CCL5
(genetics, metabolism)
- Cytokines
(immunology)
- Gene Expression
(drug effects)
- Macrophages
(drug effects, immunology, virology)
- Mice
- Theilovirus
(drug effects, immunology, physiology)
- Virus Replication
(drug effects)
|