Abstract |
Glucocorticoids (GCs) are effective anti-inflammatory agents widely used in therapeutic approach to treatment of inflammatory bowel disease (IBD). Previous results suggest that peroxisome proliferator-activated receptor [alpha] ( PPAR-[alpha]), an intracellular transcription factor activated by fatty acids, plays a role in control of inflammation. With the aim to characterize the role of PPAR-[alpha] in GC-mediated anti-inflammatory activity, we tested the efficacy of dexamethasone (DEX), a synthetic GC specific for GR, in an experimental model of IBD induced by dinitrobenzene sulfonic acid, comparing mice lacking PPAR-[alpha] ( PPAR-[alpha]KO) with wild-type (WT) mice. Results indicate that DEX-mediated anti-inflammatory activity is weakened in PPAR-[alpha]KO mice as compared with WT controls. In particular, DEX was less effective in PPAR-[alpha]KO compared with WT mice, as evaluated by inhibition of proinflammatory cytokines production, cell migration, oxidative stress, apoptosis, and colon injury. These results indicate that PPAR-[alpha] can contribute to the anti-inflammatory activity of GCs in IBD.
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Authors | Luisa Riccardi, Emanuela Mazzon, Stefano Bruscoli, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Rocco Caminiti, Carlo Riccardi, Salvatore Cuzzocrea |
Journal | Shock (Augusta, Ga.)
(Shock)
Vol. 31
Issue 3
Pg. 308-16
(Mar 2009)
ISSN: 1540-0514 [Electronic] United States |
PMID | 18665053
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Benzenesulfonates
- Cytokines
- Glucocorticoids
- Inflammation Mediators
- PPAR alpha
- dinitrobenzenesulfonic acid
- Dexamethasone
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Apoptosis
(drug effects)
- Benzenesulfonates
(toxicity)
- Cell Movement
(drug effects)
- Cytokines
(metabolism)
- Dexamethasone
(pharmacology)
- Glucocorticoids
(pharmacology)
- Inflammation Mediators
(metabolism)
- Inflammatory Bowel Diseases
(chemically induced, drug therapy, genetics, metabolism)
- Mice
- Mice, Knockout
- Oxidative Stress
(drug effects)
- PPAR alpha
(agonists, genetics, metabolism)
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