The prevalence of Th17 cells in patients with gastric cancer.

Abstract

Th17 cells have emerged as an important mediator in inflammatory and autoimmune diseases. However, recent studies suggest a potential impact of Th17 cells on tumor. The current study was designed to investigate the possible involvement of Th17 cells in gastric cancer. Compared with healthy volunteers, patients with gastric cancer had a higher proportion of Th17 cells in peripheral blood. Notably, the increased prevalence of Th17 cells was associated with clinical stage. In addition, increased populations of Th17 cells were present in tumor-draining lymph nodes with advanced disease. Furthermore, the mRNA expression levels of Th17-related factors (IL-17, IL-23p19, and RORC) in tumor tissues and the serum concentrations of IL-17 and IL-23 cytokines were significantly increased in patients with advanced gastric cancer. The results indicate that Th17 cells may contribute to gastric cancer pathogenesis.

• Authors: Bin Zhang, Guanghua Rong, Huafeng Wei, Meng Zhang, Jianwei Bi, Liye Ma, Xuchao Xue, Guo Wei, Xiaokang Liu, Guoen Fang
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 374 Issue 3 Pg. 533-7 (Sep 26 2008) ISSN: 1090-2104 [Electronic] United States
• PMID: 18655770 (Publication Type: Journal Article)

Chemical References

• Interleukin-17
• Interleukin-23 Subunit p19
• RNA, Messenger
• Receptors, Cytoplasmic and Nuclear

Topics

• Aged
• Female
• Humans
• Interleukin-17 (blood, genetics, metabolism)
• Interleukin-23 Subunit p19 (blood, genetics, metabolism)
• Male
• Middle Aged
• RNA, Messenger (metabolism)
• Receptors, Cytoplasmic and Nuclear (genetics, metabolism)
• Stomach Neoplasms (immunology, pathology)
• T-Lymphocytes, Helper-Inducer (immunology)