A case of primary hepatic Burkitt's lymphoma.

Abstract

Burkitt's lymphoma is a rare disease that belongs to the aggressive non-Hodgkin's lymphoma. Herein, we report a case of primary hepatic Burkitt's lymphoma. A 19-year-old man visited the hospital for right upper quadrant pain. He felt fatigue for two months. Physical examination revealed hepatomegaly and no palpable lymph node. He had no fever, weight loss, or night sweating. Laboratory finding showed mild anemia (hemoglobin, 12.4 g/dL), mild elevated transaminase (ALT, 52 IU/L), elevated lactate dehydrogenase (LDH, 437 IU/L), and alkaline phosphatase (ALP, 129 IU/L). The viral marker was positive for HBsAg, HBeAg, anti-HBs, and anti-HBc (IgG), and negative for anti-HBe, anti-HCV, and anti-HIV. CEA, AFP, and CA19-9 levels were within normal ranges. The HBV DNA quantitation was 1.3 x 10(9) copies/ml. Abdominal-Pelvis CT scan and abdominal MRI finding were compatible with malignant lymphoma. Liver biopsy examination confirmed Burkitt's lymphoma. No metastasis was detected in the thoracic cavity, bone marrow, and spinal fluid. The patient was treated with the combination regimen of cyclophosphamide, doxorubicin, vincristine, prednisone and high dose methotrexate. Cytosine arabinoside and methotrexate were added for CNS prophylaxis by intrathecal installation. Chemotherapy was administered every 3 weeks for fifteen cycles. Serial follow-up CT scan showed a marked decrease in the size of hepatic lesions. Follow-up CT scan and PET-CT scan were performed 4 weeks after the final cycle disclosed no definite residual or active lesion confirming the state of complete remission.

• Authors: Seung Hyun Lee, Hyung Joon Kim, Jang Sik Mun, Hyoung-Chul Oh, Hyun Woong Lee, Chang Hwan Choi, Jeong Wook Kim, Jae Hyuk Do, Jae Gyu Kim, Sae Kyung Chang, Mi Kyung Kim
• Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (Korean J Gastroenterol) Vol. 51 Issue 4 Pg. 259-64 (Apr 2008) ISSN: 1598-9992 [Print] Korea (South)
• PMID: 18516006 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Cytarabine
• Methotrexate

Topics

• Antimetabolites, Antineoplastic (therapeutic use)
• Burkitt Lymphoma (diagnosis, drug therapy, pathology)
• Combined Modality Therapy
• Cytarabine (therapeutic use)
• Diagnosis, Differential
• Humans
• Liver Neoplasms (diagnosis, drug therapy, pathology)
• Male
• Methotrexate (therapeutic use)
• Tomography, X-Ray Computed
• Young Adult