Abstract | BACKGROUND: Although studies have demonstrated that sirtinol administration following adverse circulatory conditions is known to be protective, the mechanism by which sirtinol produces the salutary effects remains unknown. We hypothesized that sirtinol administration in male rats following trauma- hemorrhage decreases cytokine production and protects against hepatic injury. METHODS: RESULTS: CONCLUSION: The salutary effects of sirtinol administration on attenuation of hepatic injury following trauma- hemorrhage are, at least in part, related to reduction of pro-inflammatory mediators.
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Authors | F-C Liu, Y-J Day, J-T Liou, Y-T Lau, H-P Yu |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 52
Issue 5
Pg. 635-40
(May 2008)
ISSN: 1399-6576 [Electronic] England |
PMID | 18419717
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzamides
- Cytokines
- Naphthols
- sirtinol
- Intercellular Adhesion Molecule-1
- Peroxidase
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Benzamides
(pharmacology)
- Cytokines
(analysis, biosynthesis)
- Hemorrhage
(drug therapy, metabolism)
- Intercellular Adhesion Molecule-1
(analysis)
- Liver
(drug effects, metabolism)
- Male
- Naphthols
(pharmacology)
- Peroxidase
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Treatment Outcome
- Wounds and Injuries
(drug therapy, metabolism)
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