Abstract | BACKGROUND: METHODS: Of ninety patients randomly allocated to treatment with either a bone-marrow or a methylprednisolone acetate injection, seventy-seven were followed for two years. The primary outcome, determined by a radiologist who was blind to the type of treatment, was radiographic evidence of healing. The cyst was judged to be either not healed (grade 1 [a clearly visible cyst] or grade 2 [a cyst that was visible but multilocular and opaque]) or healed (grade 3 [ sclerosis around or within a partially visible cyst] or grade 4 [complete healing with obliteration of the cyst]). Patient function was assessed with use of the Activity Scale for Kids, and pain was assessed with the Oucher Scale. RESULTS: Sixteen (42%) of the thirty-eight cysts treated with methylprednisolone acetate healed, and nine (23%) of the thirty-nine cysts treated with bone marrow healed (p = 0.01). There was no significant difference between the treatment groups (p > 0.09) with respect to function, pain, number of injections, additional fractures, or complications. CONCLUSIONS: Although the rate of healing of simple bone cysts was low following injection of either bone marrow or methylprednisolone, the latter provided superior healing rates.
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Authors | James G Wright, Suzanne Yandow, Sandra Donaldson, Lisa Marley, Simple Bone Cyst Trial Group |
Journal | The Journal of bone and joint surgery. American volume
(J Bone Joint Surg Am)
Vol. 90
Issue 4
Pg. 722-30
(Apr 2008)
ISSN: 1535-1386 [Electronic] United States |
PMID | 18381307
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Methylprednisolone Acetate
- Methylprednisolone
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Topics |
- Anti-Inflammatory Agents
(administration & dosage)
- Bone Cysts
(therapy)
- Bone Marrow Transplantation
(methods)
- Child
- Humans
- Injections, Intralesional
- Methylprednisolone
(administration & dosage, analogs & derivatives)
- Methylprednisolone Acetate
- Prospective Studies
- Treatment Outcome
- Wound Healing
(drug effects)
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