Methylprednisolone Acetate (Depo-Medrol)

Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.

Also Known As:

Depo-Medrol; Acetyl-Methylprednisolone; Depo-Medrone; Methylprednisolone Acetate, (11beta,16alpha)-isomer; Methylprednisolone Acetate, (11beta,16beta)-isomer; Methylprednisolone-21-acetate; Acetyl Methylprednisolone; Depo Medrol; Depo Medrone; Methylprednisolone 21 acetate; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-

Networked: 373 relevant articles (35 outcomes, 42 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienetriols
        Prednisolone: 12013
        Methylprednisolone: 7513
        Methylprednisolone Acetate: 373

Experts

1.	Brandt, Mary E: 7 articles (02/2015 - 05/2013)
2.	Habib, George: 6 articles (01/2018 - 12/2013)
3.	Artul, Suheil: 5 articles (01/2018 - 01/2014)
4.	Jabbour, Adel: 5 articles (04/2017 - 12/2013)
5.	Malani, Anurag N: 5 articles (10/2015 - 06/2013)
6.	Khazin, Fadi: 4 articles (01/2018 - 03/2014)
7.	Smith, Rachel M: 4 articles (10/2015 - 12/2012)
8.	Park, Benjamin J: 4 articles (06/2015 - 12/2012)
9.	Gade, Lalitha: 4 articles (02/2015 - 05/2013)
10.	Litvintseva, Anastasia P: 4 articles (02/2015 - 05/2013)

Related Diseases

1.	Pain (Aches) 05/01/2023 - "The mean SPADI score was 53.32 ± 7.49 in the PRP group and 59.24 ± 5.80 in the methylprednisolone acetate group (P≤0.001), indicating a significant improvement in the PRP group's pain and disability scores after 24 weeks. " 06/01/2004 - "To establish whether a local injection of methylprednisolone acetate (40 mg) is effective in decreasing pain during running in runners with recent onset (less than two weeks) iliotibial band friction syndrome (ITBFS). " 01/01/2020 - "There was low quality evidence from one study [n = 78] of moderate reduction in disability and small reduction in pain with early (within 72 hr of symptom onset) single intramuscular administration of methylprednisolone acetate; MD -24.5 [-38.8, -10.2] and -14.0 [-27.4, -0.6], respectively. " 04/01/2017 - "The effect of local injection of methylprednisolone acetate on the hypothalamic-pituitary-adrenal axis among patients with greater trochanteric pain syndrome." 07/28/2015 - "Knee pain flexion reflex threshold, and quadriceps peak torque were measured at baseline, immediately after knee joint aspiration alone and 5 ± 2 and 15 ± 2 days after knee joint aspiration and the injection of 40 mg of methylprednisolone acetate. "
2.	Arthritis (Polyarthritis) 01/01/2017 - "Efficacy of Methylprednisolone Acetate Versus Triamcinolone Acetonide Intra-articular Knee Injection in Patients With Chronic Inflammatory Arthritis: A 24-Week Randomized Controlled Trial." 03/01/1987 - "Intra-articular treatment of inflammatory arthritis: double-blind trial comparing bufexamac with methylprednisolone acetate." 09/01/2016 - "Therefore, the new synthesized Depo Medrol-chitosan is an applicable appliance for arthritis therapy by slow release mechanism. " 03/01/2010 - "To evaluate whether treating patients with very early inflammatory polyarthritis (IP) with a 3-week course of intramuscular (IM) methylprednisolone acetate may postpone the need for disease-modifying antirheumatic drugs (DMARDs) and prevent IP from evolving into rheumatoid arthritis (RA). " 10/01/2017 - "Inflammatory arthritis or osteoarthritis of the knee - Efficacy of intra-joint infiltration of methylprednisolone acetate versus triamcinolone acetonide or triamcinolone hexacetonide."
3.	Bone Cysts (Bone Cyst) 01/01/1984 - "Contrast examination was helpful in predicting the response of solitary bone cysts to treatment by injection of methylprednisolone-acetate (MPA). " 01/01/2005 - "Thirteen children (9 boys, 4 girls; mean age 9 years; range 4 to 14 years) with simple bone cysts were treated primarily with injection of methylprednisolone acetate with the use of the two-needle technique. " 01/01/2005 - "[Treatment of simple bone cysts with methylprednisolone acetate in children]." 06/01/1999 - "Injection of radiopaque contrast into a solitary bone cyst (SBC) prior to methylprednisolone acetate (MPA) injection has been previously reported. " 02/01/1991 - "Simple bone cysts can be treated satisfactorily with injection of methylprednisolone acetate, thus obviating surgery."
4.	Knee Osteoarthritis 12/01/2016 - "The use of an intra-articular methylprednisolone acetate (MPA) injection has been shown to have benefits for symptoms of knee osteoarthritis (OA). " 03/01/2014 - "The objective of this study was to evaluate the effect of simultaneous bilateral intra-articular injection (IAI) of methylprednisolone acetate (MPA) on the hypothalamic-pituitary-adrenal axis in patients with knee osteoarthritis. " 01/01/2017 - "Therapeutic Review of Methylprednisolone Acetate Intra-Articular Injection in the Management of Osteoarthritis of the Knee - Part 1: Clinical Effectiveness." 12/01/2016 - "Therapeutic Review of Methylprednisolone Acetate Intra-Articular Injection in the Management of Osteoarthritis of the Knee - Part 2: Clinical and Procedural Considerations." 01/01/2014 - "The objective of this study was to evaluate the effect of intra-articular corticosteroid injection (IACI) of methylprednisolone acetate (MPA) on the hypothalamic-pituitary-adrenal (HPA) axis in patients with osteoarthritis of the knee. "
5.	Intervertebral Disc Displacement (Herniated Disc) 01/01/2009 - "Thirty-eight dogs with Hansen type II lumbosacral disc protrusion were treated with epidural infiltration of methylprednisolone acetate between the seventh lumbar vertebra and the sacrum. " 07/01/1992 - "In this study, 84 consecutively treated, comparable patients with unilateral lumbar disc herniation were prospectively assigned randomly to receive either epidural corticosteroids (40 mg methylprednisolone acetate) or saline at the conclusion of the operative procedure. " 01/01/2011 - "Comparing the effects of epidural methylprednisolone acetate injected in patients with pain due to lumbar spinal stenosis or herniated disks: a prospective study." 10/01/2023 - "This study retrospectively compared particulate steroids, methylprednisolone acetate (mid-term effective), against betamethasone acetate (long-term effective) on ultrasound-guided caudal epidural injection for lumbar disc herniation. " 01/01/2011 - "This randomized comparative blinded study was undertaken to compare the efficacy of caudal methylprednisolone acetate with triamcinolone acetonide and dexamethasone acetate, for pain relief for sciatica associated with lumbar-disk herniations. "

Related Drugs and Biologics

1.	Triamcinolone Acetonide (Azmacort)
2.	Steroids
3.	Methylprednisolone Acetate (Depo-Medrol)
4.	Methylprednisolone
5.	Lidocaine (Xylocaine)
6.	triamcinolone hexacetonide (Aristospan)
7.	Suspensions
8.	Prednisolone (Predate)
9.	Adrenal Cortex Hormones (Corticosteroids)
10.	Bupivacaine (Bupivacaine Hydrochloride)

Related Therapies and Procedures

1.	Intra-Articular Injections
2.	Therapeutics
3.	Epidural Injections
4.	Bone Transplantation (Bone Grafting)
5.	Curettage