Abstract | BACKGROUND:
Eosinophilic fasciitis is a rare scleroderma-like illness. The clinical spectrum of the disease has evolved since its initial description. METHODS: We identified all patients diagnosed with eosinophilic fasciitis over the past 10 years at our scleroderma clinic. Demographics, disease pattern, serologies, tissue pathology and reponse to treatment were all recorded. RESULTS: Twelve patients with eosinophilic fasciitis were identified in our clinic over the past 10 years. The mean age at diagnosis was 49.8 +/- 9.8 years, with nine female and three male patients. The first symptoms were noticed at an average of 8.8 +/- 6.1 months before diagnosis. The mean initial absolute peripheral blood eosinophil count was 1188 +/- 1059 cells/L. Two patients had a monoclonal gammopathy, and two had positive ANA titers. All patients received corticosteroids, 10 of whom received the equivalent dose of > 20 mg/day of prednisone for more than a month. Five patients received hydroxychloroquine, two received methotrexate, one received cyclosporine, one received topical tacrolimus, and one received sulfasalazine. At a mean follow up of 17.6 months (range 2-94 months), 8 patients had a good response to treatment, 2 patients had no effect, and 2 patients had a poor response to treatment. CONCLUSION:
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Authors | Lindsay Bischoff, Chris T Derk |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 47
Issue 1
Pg. 29-35
(Jan 2008)
ISSN: 1365-4632 [Electronic] England |
PMID | 18173597
(Publication Type: Journal Article, Review)
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Chemical References |
- Autoantibodies
- Glucocorticoids
- Immunosuppressive Agents
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Topics |
- Adult
- Autoantibodies
(blood)
- Drug Therapy, Combination
- Eosinophilia
(complications, drug therapy, pathology)
- Eosinophils
- Fasciitis
(complications, drug therapy, pathology)
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Paraproteinemias
(complications)
- Retrospective Studies
- Skin
(pathology)
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