The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus.

Abstract

Although many studies which explore on the interaction between stress and antinociception have been conducted, most of them do not divide stress into emotional stress (ES) and physical stress (PS). In the present study, we investigated the differential effects of ES or PS on pain behaviors or on c-Fos immunoreactivity (IR) in the paraventricular nucleus (PVN) or arcuate nucleus (ArcN) using electrical footshock-witness model. In addition, alteration of pain behaviors or c-Fos IR following stress repetition was examined. The electrical foot shock was applied to PS animal group in one chamber, whereas the witness animal group in another chamber without any electrical foot shock was regarded as an ES. In each group, either single (10 stimuli /10 min/1 day) or repeated stress for 5 consecutive days was applied. Our results suggest that ES and PS appear to play differential roles in the regulation of nociception produced by various types of pain stimuli (formalin, substance P, glutamate or pro-inflammatory cytokines) and on c-Fos IR in the PVN or ArcN. Moreover, such antinociceptive effect or c-Fos IR appears to be modified following stress repetition.

• Authors: Min-Soo Kwon, Young-Jun Seo, Eon-Jeong Shim, Jin-Koo Lee, Jeong-Eun Jang, Soo-Hyun Park, Jun-Sub Jung, Hong-Won Suh
• Journal: Brain research (Brain Res) Vol. 1190 Pg. 122-31 (Jan 23 2008) ISSN: 0006-8993 [Print] Netherlands
• PMID: 18086467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-1beta
• Proto-Oncogene Proteins c-fos
• Tumor Necrosis Factor-alpha
• Substance P
• Glutamic Acid
• Interferon-gamma

Topics

• Analysis of Variance
• Animals
• Arcuate Nucleus of Hypothalamus (metabolism)
• Chronic Disease
• Disease Models, Animal
• Glutamic Acid (administration & dosage, adverse effects)
• Immunohistochemistry
• Injections, Spinal
• Interferon-gamma (administration & dosage, adverse effects)
• Interleukin-1beta (administration & dosage, adverse effects)
• Male
• Mice
• Mice, Inbred ICR
• Pain (chemically induced, complications, metabolism, psychology)
• Pain Threshold (physiology, psychology)
• Paraventricular Hypothalamic Nucleus (metabolism)
• Proto-Oncogene Proteins c-fos (metabolism)
• Statistics, Nonparametric
• Stress, Psychological (complications, metabolism, psychology)
• Substance P (administration & dosage, adverse effects)
• Tumor Necrosis Factor-alpha (administration & dosage, adverse effects)