The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis.

Abstract

BACKGROUND:

The pathobiology of rheumatoid arthritis (RA) is similar to that of periodontitis in that proinflammatory cytokines and immunoglobulin G Fc receptor (FcgammaR) play an important role. Functional polymorphisms of interleukin (IL)-1 and FcgammaR were shown to be associated with susceptibility to both diseases. Therefore, we evaluated whether the IL-1 and FcgammaR gene polymorphisms represent a common risk factor for RA and periodontitis.

METHODS:

The study population consisted of Japanese adults with RA (RA group; N = 100), periodontitis only (P group; N = 100), and healthy individuals with no systemic or oral disease (H group; N = 100). Clinical periodontal condition was defined by measurements of probing depth, clinical attachment level, and bleeding on probing. Genomic DNA was isolated from peripheral blood and analyzed for determination of IL-1 genotypes (IL-1A+4845, IL-1B+3954, and IL-1RN+2028) and FcgammaR genotypes (FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB) by allele-specific polymerase chain reactions.

RESULTS:

Among 100 patients with RA, 86% showed periodontal tissue destruction. However, the RA group exhibited milder levels of periodontal tissue destruction than the P group (P <0.01). There was a significant difference in the distribution of IL-1B+3954 C/T genotypes between the RA and P groups and between the RA and H groups (P = 0.03 for both comparisons), with enrichment of the T allele in the RA group (P = 0.04; odds ratio, 2.9 for both comparisons). The combination of IL-1A+4845 T and IL-1+3954 T alleles yielded a strong association with RA and periodontitis (RA versus P group: P = 0.00001; RA versus H group: P = 0.00001).

CONCLUSIONS:

These results failed to show that IL-1 and FcgammaR gene polymorphisms constitute a common risk factor for RA and periodontitis. However, it was suggested that the distributions of IL-1B+3954 genotypes and IL-1A+4845 and IL-1B+3954 haplotypes were unique to the patients with RA and periodontitis.

• Authors: Tetsuo Kobayashi, Satoshi Ito, Takeshi Kuroda, Kouji Yamamoto, Noriko Sugita, Ichiei Narita, Takayuki Sumida, Fumitake Gejyo, Hiromasa Yoshie
• Journal: Journal of periodontology (J Periodontol) Vol. 78 Issue 12 Pg. 2311-8 (Dec 2007) ISSN: 0022-3492 [Print] United States
• PMID: 18052703 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-1alpha
• Interleukin-1beta
• Receptors, IgG

Topics

• Adult
• Aged
• Alleles
• Arthritis, Rheumatoid (complications, genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Humans
• Interleukin-1alpha (genetics)
• Interleukin-1beta (genetics)
• Japan
• Male
• Middle Aged
• Periodontitis (complications, genetics)
• Polymorphism, Genetic
• Receptors, IgG (genetics)
• Statistics, Nonparametric