Abstract | BACKGROUND: METHODS: We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance ( RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively. RESULTS: The average age of the study population was 62.2+/-11.4 years in AMI patients and 62.6+/-10.4 years in healthy controls. Multiple logistic regression analysis with risk factors such as age, male sex, smoking, hypertension, diabetes mellitus, and dyslipidemia revealed the PAPP-A IVS6+95 C allele to be associated with an increased risk of AMI (dominancy: odds ratio, 2.13; 95% confidence interval, 1.12-4.07; P=0.022; codominancy: odds ratio, 1.89; 95% confidence interval, 1.14-3.16; P=0.015). CONCLUSIONS: We found, for the first time, that PAPP-A IVS6+95 C allele is an independent risk factor for AMI even after adjustment for traditional risk factors. The determination of such genotype contributing to AMI could provide a new tool for identifying high-risk individuals.
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Authors | Sungha Park, Jong-Chan Youn, Dong-Jik Shin, Chan-Mi Park, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Jong-Won Ha, Yangsoo Jang, Namsik Chung |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 18
Issue 6
Pg. 417-22
(Sep 2007)
ISSN: 0954-6928 [Print] England |
PMID | 17700210
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pregnancy-Associated Plasma Protein-A
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Topics |
- Aged
- Alleles
- Case-Control Studies
- Female
- Genotype
- Haplotypes
- Humans
- Logistic Models
- Male
- Middle Aged
- Myocardial Infarction
(genetics)
- Polymorphism, Single Nucleotide
(genetics)
- Pregnancy-Associated Plasma Protein-A
(genetics)
- Risk Factors
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