Abstract | BACKGROUND: The purpose was to evaluate the efficacy of tumor volumetry on MRI as predictive of response to treatment with induction chemotherapy, comparing the results with endoscopy. METHODS: Fifty patients with advanced squamous cell carcinoma of the head and neck (SSCHN) who underwent MRI volumetry before and after neoadjuvant chemotherapy consisting of docetaxel, cisplatin, and 5-fluorouracil (TPF) were included in this study. The tumor volume was calculated by a slice-by-slice evaluation. With the standard software of a workstation, the area of the tumor was measured slice by slice using manual segmentation. To evaluate the efficacy of MRI volumetry, pretreatment volume was compared with pretreatment remission status as evaluated with endoscopy. RESULTS: Forty-five (90%) patients demonstrated a tumor downstaging after chemotherapy. Fourteen (28%) patients showed a complete histologic remission (CR), 31 (62%) patients showed a partial remission (PR). Pretreatment tumor volume was significantly different between patients whose tumor completely responded (CR) and those whose tumor did not completely respond or whose disease was stable or was progressive (p = .00023). We defined a threshold for the pretreatment tumor volume in patients with CR, which was equal to 29.71 cc. CONCLUSION:
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Authors | Mehran Baghi, Martin G Mack, Markus Hambek, Sotirios Bisdas, Ramona Muerthel, Jens Wagenblast, Wolfgang Gstoettner, Thomas Vogl, Rainald Knecht |
Journal | Head & neck
(Head Neck)
Vol. 29
Issue 2
Pg. 104-8
(Feb 2007)
ISSN: 1043-3074 [Print] United States |
PMID | 17111434
(Publication Type: Journal Article)
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Chemical References |
- Taxoids
- Docetaxel
- Cisplatin
- Fluorouracil
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma, Squamous Cell
(drug therapy, pathology)
- Cisplatin
(administration & dosage)
- Docetaxel
- Endoscopy
- Female
- Fluorouracil
(administration & dosage)
- Head and Neck Neoplasms
(drug therapy, pathology)
- Humans
- Image Processing, Computer-Assisted
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm, Residual
- Prognosis
- Remission Induction
- Taxoids
(administration & dosage)
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