[High incidence of fatal cytokine-related disease among children with sequelae of perinatal hypoxic-ischemic encephalopathy].

Abstract

Children with sequelae of perinatal hypoxic-ischemic encephalopathy (HIE) occasionally suffer from cytokine-related disease. We investigated 12 children with perinatal HIE sequelae, who died in childhood, concerning (1) the incidence of cytokine-related disease as the cause of death, and (2) the characteristics of the cytokine-related disease. Six (50%) of the 12 patients died from cytokine-related disease:two had virus-associated hemophagocytic syndrome (VAHS) ; one had acute encephalopathy;one had systemic inflammatory response syndrome (SIRS); and two had severe pneumonia/acute respiratory distress syndrome (ARDS). These six patients presented with increased liver transaminase, LDH, and CK, and decreased platelet count and albumin. This study shows the high incidence of cytokine-related disease as the cause of death in children with perinatal HIE sequelae. Further investigation is needed to clarify the pathogenesis of this disease.

• Authors: Motomasa Suzuki, Fumio Hayakawa, Akihisa Okumura, Toru Kato, Tetsuo Kubota, Koichi Maruyama
• Journal: No to hattatsu = Brain and development (No To Hattatsu) Vol. 38 Issue 6 Pg. 439-42 (Nov 2006) ISSN: 0029-0831 [Print] Japan
• PMID: 17094563 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytokines
• Serum Albumin

Topics

• Basal Ganglia Diseases (etiology)
• Brain Damage, Chronic (complications)
• Cytokines (blood)
• Encephalomalacia (etiology)
• Female
• Humans
• Hypoxia, Brain (complications)
• Infant Mortality
• Infant, Newborn
• Lymphohistiocytosis, Hemophagocytic (etiology)
• Male
• Respiratory Distress Syndrome, Newborn (complications)
• Serum Albumin (analysis)
• Sudden Infant Death
• Systemic Inflammatory Response Syndrome (etiology)