Hormonal activity of AIMP1/p43 for glucose homeostasis.

Abstract

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic alpha cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

• Authors: Sang Gyu Park, Young Sun Kang, Jin Young Kim, Chang Seok Lee, Young Gyu Ko, Woo Je Lee, Ki-Up Lee, Young Il Yeom, Sunghoon Kim
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 103 Issue 40 Pg. 14913-8 (Oct 03 2006) ISSN: 0027-8424 [Print] United States
• PMID: 17001013 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aimp1 protein, mouse
• Cytokines
• Glucagon
• Glucose

Topics

• 3T3-L1 Cells
• Animals
• Cytokines (deficiency, metabolism)
• Gene Expression Profiling
• Glucagon (blood)
• Glucagon-Secreting Cells (cytology, metabolism, ultrastructure)
• Glucose (metabolism)
• Glycogenolysis (physiology)
• Homeostasis (physiology)
• Hypoglycemia
• Lipolysis (physiology)
• Male
• Mice
• Mice, Inbred C57BL
• Phenotype
• Protein Transport